ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
2 files
0/0

Catalytic Alkyne Arylation Using Amines as Traceless Directing Groups

preprint
submitted on 03.05.2018 and posted on 03.05.2018 by Jung-Woo Park, Bubwoong Kang, Vy M. Dong
By developing a Pd(0)/Mandyphos catalyst, we have achieved a three-component aminoarylation of alkynes to generate enamines, which upon hydrolysis yield either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes well-established pathways to enable the use of amines as traceless directing groups for C–C bond formation.

Funding

National Science Foundation (CHE-1465263), Institute for Basic Science (IBS-R10-Y1)

History

Email Address of Submitting Author

jwpark84@gmail.com

Email Address(es) for Other Author(s)

bubwoongk@uci.edu dongv@uci.edu

Institution

Department of Chemistry, UC Irvine; Center for Catalytic Hydrocarbon Functionalizations, IBS

Country

USA; Korea(South)

ORCID For Submitting Author

0000-0002-4019-217X

Declaration of Conflict of Interest

The authors declare no competing financial interests.

Exports