Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2

A novel carbon-11 carboxylation radiosynthesis methodology is described with the potential to be used to produce in vivo molecular imaging radiotracers for positron emission tomography. This is a simple and rapid method for incorporating carbon-11 labelling precursors such as [11C]carbon dioxide and [11C]methyl iodide into fluoride-activated silanes.