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Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2
preprintsubmitted on 16.12.2019, 13:30 and posted on 20.12.2019, 09:04 by Salvatore Bongarzone, Nicola Raucci, Igor Fontana, Federico Luzi, Antony Gee
A novel carbon-11 carboxylation radiosynthesis methodology is described with the potential to be used to produce in vivo molecular imaging radiotracers for positron emission tomography. This is a simple and rapid method for incorporating carbon-11 labelling precursors such as [11C]carbon dioxide and [11C]methyl iodide into fluoride-activated silanes.