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Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2

preprint
submitted on 16.12.2019 and posted on 20.12.2019 by Salvatore Bongarzone, Nicola Raucci, Igor Fontana, Federico Luzi, Antony Gee
A novel carbon-11 carboxylation radiosynthesis methodology is described with the potential to be used to produce in vivo molecular imaging radiotracers for positron emission tomography. This is a simple and rapid method for incorporating carbon-11 labelling precursors such as [11C]carbon dioxide and [11C]methyl iodide into fluoride-activated silanes.

Funding

MR/K022733/1

FP7-PEOPLE-2012-ITN 316882

WT 088641/Z/09/Z

History

Email Address of Submitting Author

salvatore.bongarzone@kcl.ac.uk

Institution

King's College London

Country

United Kingdom

ORCID For Submitting Author

0000-0002-1309-3045

Declaration of Conflict of Interest

None

Exports