Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2

20 December 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A novel carbon-11 carboxylation radiosynthesis methodology is described with the potential to be used to produce in vivo molecular imaging radiotracers for positron emission tomography. This is a simple and rapid method for incorporating carbon-11 labelling precursors such as [11C]carbon dioxide and [11C]methyl iodide into fluoride-activated silanes.

Keywords

Carbon-11
silane compound
fluoride anion
carboxylic acid chemical function
[11C]CO2 fixation-reduction
Positron Emission Tomography

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