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Capsaicin Entrapment in Metal-Organic Framework Material Derived from γ-Cyclodextrin

preprint
submitted on 20.11.2019 and posted on 28.11.2019 by Gangothri Venkataswamy, Nisha kiran Meena, Kavya K Naik, Nanishankar Harohally

Capsaicin, a pungent molecule from red chilli is known for its therapeutic benefits. However, poor aqueous solubility coupled with inherent pungency has limited its applications. We envisaged, encapsulation of capsaicin in biocompatible MOF material derived from γ-cyclodextrin (γ-CD) to overcome solubility and pungency attributes. Encapsulation of capsaicin was accomplished via crystal growth achieved by vapour diffusion of ethanol to synthesis solution consisting of γ-CD, KOH and capsaicin.The accomplished MOF Caps@γ-CDMOF was thoroughly characterized in solid state by powder X-ray diffraction (PXRD), IR, DSC, SEM and in solution by UV, fluorescence, NMR spectroscopic techniques. The encapsulation of capsaicin was found to be slightly higher than 3:1 (γ-CD: capsaicin ratio) in Caps@γ-CDMOF.

History

Email Address of Submitting Author

nani.shankar@gmail.com

Institution

CSIR-Central Food Technological Research Institute

Country

India

ORCID For Submitting Author

0000-0003-2306-5897

Declaration of Conflict of Interest

No conflict of interest

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