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Can Gold Nanoparticles Aid Electrophoretic Detection of Sulphur in Biomolecules? Development of Gold-PAGE

preprint
submitted on 04.04.2018 and posted on 05.04.2018 by Emerald R. Tayor, Silvia Cavuoto, David M. Beal, Sophie Caujolle, Adrian Podoleanu, Christopher Serpell

The prevalence, distinctive reactivity, and biological significance of sulphur-based groups in proteins and nucleic acids means that analysis of sulphur is of prime importance in biochemistry, biotechnology, and medicine. We report steps in the development of a method to detect these moieties using gold nanoparticles as adjuncts in polyacrylamide gel electrophoresis (Gold-PAGE).

Funding

E. R. Taylor thanks the Leverhulme Trust for support under a Research Project Grant (RPG-2017-188). We are grateful for the University of Kent and the Royal Society of Chemistry Research Fund for monetary support. D. M. Beal thanks the BBSRC (BB/M009815/1) for financial support. S. Caujolle and A. Podoleanu acknowledge the UBAPHODESA Marie Curie European Industrial Doctorate 607627.

History

Email Address of Submitting Author

c.j.serpell@kent.ac.uk

Institution

University of Kent

Country

UK

ORCID For Submitting Author

0000-0002-2848-9077

Declaration of Conflict of Interest

There are no conflicts of interest to declare.

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