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Can Gold Nanoparticles Aid Electrophoretic Detection of Sulphur in Biomolecules? Development of Gold-PAGE

05 April 2018, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The prevalence, distinctive reactivity, and biological significance of sulphur-based groups in proteins and nucleic acids means that analysis of sulphur is of prime importance in biochemistry, biotechnology, and medicine. We report steps in the development of a method to detect these moieties using gold nanoparticles as adjuncts in polyacrylamide gel electrophoresis (Gold-PAGE).

Keywords

Gold Nanoparticles
Gel electrophoresis
DNA affinity

Supplementary materials

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Description
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Title
Gold-PAGE preprint ESI
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Now Published

Development of Gold-PAGE: towards the electrophoretic analysis of sulphurous biopolymers [opens in a new tab]
Emerald R. Taylor, Silvia Cavuoto, David M. Beal, Sophie Caujolle, Adrian Podoleanu, Christopher J. Serpell journal article
Journal of Materials Chemistry B , Volume 7, Issue 34
Online publication date: 2019

Version History

Apr 05, 2018 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.6086531.v1
D O I: 10.26434/chemrxiv.6086531.v1 [opens in a new tab]

Funding

E. R. Taylor thanks the Leverhulme Trust for support under a Research Project Grant (RPG-2017-188). We are grateful for the University of Kent and the Royal Society of Chemistry Research Fund for monetary support. D. M. Beal thanks the BBSRC (BB/M009815/1) for financial support. S. Caujolle and A. Podoleanu acknowledge the UBAPHODESA Marie Curie European Industrial Doctorate 607627.

Author’s competing interest statement

There are no conflicts of interest to declare.

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