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C–H Functionalization Approach for the Synthesis of Chiral C2 Symmetric 1,5-Cyclooctadienes Ligands

preprint
submitted on 23.10.2019, 23:33 and posted on 28.10.2019, 21:30 by Bowen Zhang, Michael Hollerbach, Simon Blakey, Huw Davies
Chiral cyclooctadiene (COD) derivatives are readily prepared by rhodium-catalyzed allylic C-H functionalization of COD. Either mono or difunctionalization of COD is possible generating the products in high yield, diastereoselectivity and enantioselectivity.

Funding

NSF CCI Phase II Center for Selective C—H Functionalization (CHE-1700982)

NSF (CHE 1531620)

NSF (CHE 1626172)

History

Email Address of Submitting Author

hmdavie@emory.edu

Institution

Emory University

Country

United States

ORCID For Submitting Author

0000-0001-6254-9398

Declaration of Conflict of Interest

HMLD is a named inventor on a patent entitled, Dirhodium Catalyst Compositions and Synthetic Processes Related Thereto (US 8,974,428, issued March 10, 2015).

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