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CO2-Enabled Cyanohydrin Synthesis and Facile Homologation Reactions

preprint
submitted on 14.07.2020 and posted on 15.07.2020 by Martin Juhl, Allan Petersen, JIWOONG LEE
Thermodynamic and kinetic control of a chemical process is the key to access desired products and states. Changes are made when desired product is not accessible; one may manipulate the reaction with additional reagents, catalysts and/or protecting groups. Here we report the use of carbon dioxide to direct reaction pathways in order to selectively afford desired products in high reaction rates while avoiding the formation of byproducts. The utility of CO2-mediated selective cyanohydrin synthesis was further showcased by broadening Kiliani-Fischer synthesis to offer an easy access to variety of polyols, cyanohydrins, linear alkylnitriles, by simply starting from alkyl- and arylaldehydes, KCN and atmospheric pressure of CO2.

Funding

Novo Nordisk Fonden

Villum Fonden

History

Email Address of Submitting Author

jiwoong.lee@chem.ku.dk

Institution

University of Copenhagen

Country

Denmark

ORCID For Submitting Author

0000-0001-6177-4569

Declaration of Conflict of Interest

The authors declare no conflict of interest

Version Notes

version1.0

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