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Broad Assessment of Bioactivity of a Collection of Spiroindane Pyrrolidines Through “Cell Painting”

preprint
submitted on 12.03.2020 and posted on 13.03.2020 by Zarko Boskovic, Manvendra Singh, Zachary Pearson, Nathan Garza
A collection of small molecules has been synthesized by composing photo-cycloaddition, C-H functionalization, and N-capping strategies. Multidimensional biological fingerprints of molecules comprising this collection have been recorded as changes in cell and organelle morphology. This untargeted, phenotypic approach allowed for a broad assessment of biological activity to be determined. Reproducibility and the magnitude of measured fingerprints revealed activity of several treatments. Reactive functional groups, such as imines, dominated the observed activity. Two non-reactive candidate compounds with distinct bioactivity fingerprints were identified, as well.

History

Email Address of Submitting Author

zarko@ku.edu

Institution

University of Kansas

Country

United States

ORCID For Submitting Author

0000-0001-9376-527X

Declaration of Conflict of Interest

no conflict of interest

Exports