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Bioinformatics-Guided Discovery of Citrulline 4-Hydroxylase from GE81112 Biosynthesis and Rational Engineering of Its Substrate Specificity

preprint
submitted on 19.08.2019 and posted on 20.08.2019 by Christian Zwick, Max Sosa, Hans Renata
We functionally characterize a nonheme dioxygenase from GE81112 biosynthesis and identify it as a citrulline hydroxylase. A bioinformatics guided engineering was performed to alter the substrate specificity of the enzyme.

Funding

Biocatalytic C -H Functionalization Logic in the Chemoenzymatic Synthesis of Therapeutic Natural Products

National Institute of General Medical Sciences

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History

Email Address of Submitting Author

hrenata@scripps.edu

Institution

The Scripps Research Institute

Country

USA

ORCID For Submitting Author

0000-0003-2468-2328

Declaration of Conflict of Interest

No conflict of interest

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