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Bioinformatics-Guided Discovery of Citrulline 4-Hydroxylase from GE81112 Biosynthesis and Rational Engineering of Its Substrate Specificity
preprintsubmitted on 19.08.2019, 18:29 and posted on 20.08.2019, 16:19 by Christian Zwick, Max Sosa, Hans Renata
We functionally characterize a nonheme dioxygenase from GE81112 biosynthesis and identify it as a citrulline hydroxylase. A bioinformatics guided engineering was performed to alter the substrate specificity of the enzyme.
Biocatalytic C -H Functionalization Logic in the Chemoenzymatic Synthesis of Therapeutic Natural Products
National Institute of General Medical SciencesFind out more...