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Biodegradable Poly(ester) Urethane Acrylate Resins for Digital Light Processing: From Polymer Synthesis to 3D Printed Tissue Engineering Constructs

preprint
submitted on 31.03.2020 and posted on 01.04.2020 by Matthew Baker, Rong Wang, Febriyani Damanik, Tobias Kuhnt, Hans Ippel, Piet Dijkstra, Tessa ten Cate, Aylvin Dias, Lorenzo Moroni
Digital light processing (DLP) is one of the most accurate and fastest additive manufacturing
technologies to produce a variety of products, from patient-customized biomedical implants to
consumer goods; however, DLP’s use in tissue engineering is limited largely due to a lack of
biodegradable resins. Herein, a library of biodegradable urethane acrylate-capped poly(esters)
(with variations in molecular weight) is investigated as the basis for a DLP printable ink for
tissue engineering. The synthesized oligomers show good printability in a DLP resin, capable
of creating complex structures with mechanical properties matching those of medium-soft
tissues (1–3 MPa). While fabricated films from different molecular weight resins showed few
differences in surface topology, wettability, and protein adsorption, the adhesion and metabolic
activity of L929 and human dermal fibroblasts (HDFs) were significantly different: resins from
higher molecular weight oligomers provided greater cell adhesion and metabolic activity. These
printable and biodegradable resins show the importance of oligomer molecular weight on
scaffold properties, and facilitate the printing of elastomeric customizable scaffolds for a variety
of tissue engineering applications.

Funding

Province of Limburg

Brightlands Materials Center

History

Email Address of Submitting Author

m.baker@maastrichtuniversity.nl

Institution

Maastricht University

Country

the Netherlands

ORCID For Submitting Author

0000-0003-1731-3858

Declaration of Conflict of Interest

A. Dias (DSM Biomedical) is co-inventor on a patent (EP 2089438B, US 9458256) related to the creation of polymeric urethanes

Exports