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Biocatalytic Ketone Reductions Using Biobeads

preprint
submitted on 27.07.2020, 15:17 and posted on 05.08.2020, 13:14 by Jia Shen Chew, Ken Chi Lik Lee, THI THANH NHA HO

Lee and coworkers offers a kind of new concept to enzyme immobilization and explores its suitability in the context of miniaturisation and high-throughput screening. Here, polystyrene-immobilized ketoreductases are compared with its non-immobilized counterparts in terms of conversion and stereoselectivity (both determined by chiral HPLC), and the study indicates that the BioBeads perform similarly (sometimes slightly more selective) which may be useful whenever defined micro-scale amounts of biocatalysts were required in high-throughput experiment settings.

Funding

Ministry of Education (MOE) AcRF Tier 1 funding (Grant Number 2019-T1-002-114

History

Email Address of Submitting Author

jchew025@e.ntu.edu.sg

Institution

Nanyang Technological University

Country

Singapore

ORCID For Submitting Author

0000-0001-8954-7798

Declaration of Conflict of Interest

No conflict of interest

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