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submitted on 07.06.2020 and posted on 11.06.2020by Jie Feng, Ding Du, Kuili Zhang, Jian Gao, Tao Lu, Rui Ma, Zhihao Shi
An NHC and photo-redox co-catalyzed α-amino acid
decarboxylative carbonylation reaction was presented here. This method displayed
good scope generality, providing an easy and direct pathway to access various
downstream α-amino ketones from readily accessible starting materials under bio- and medicinally compatible conditions. Moreover, this
strategy is appealing to chemical biology since it
has great potential for chemical modification of peptides or late-stage
synthesis of keto-peptides.