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Silicon incorporation in polymethine dyes

preprint
revised on 31.03.2020 and posted on 03.04.2020 by Monica Pengshung, Patrick Neal, Timothy Atallah, Junho Kwon, Justin Caram, Steven Lopez, Ellen Sletten

Methods to red-shift fluorophores have garnered considerable interest due to the broad utility of low energy light. The incorporation of silicon into xanthene and coumarin scaffolds has resulted in an array of visible and near-infrared fluorophores. Here, we extend this approach to polymethine dyes, another popular fluorophore class, performing experimental and computational analyses. We found that when oxygen was replaced with SiMe2, bathochromic shifts of up to 121 nm and fluorophores with emission above 900 nm were achieved.

Funding

Sloan Research Award FG-2018-10855

NIH 1R01EB027172-01

NSF MRI CHE-1048804

NIH (1S10OD016387-01)

UCLA

NSF 1940307

DOE BES-SC0019245

History

Email Address of Submitting Author

sletten@chem.ucla.edu

Institution

University of California, Los Angeles

Country

USA

ORCID For Submitting Author

0000-0002-0049-7278

Declaration of Conflict of Interest

No conflicts of interest

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