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Base-Mediated Generation of Ketenimines from Ynamides: Addition of Hydrazones to Give Acetimidohydrazides
preprintsubmitted on 05.03.2021, 21:49 and posted on 08.03.2021, 13:18 by Capucine Mahe, Agathe C. A. D’Hollander, Kevin Cariou
Under basic conditions, N-arylketenimines were generated in situ from N-Boc ynamides and reacted with hydrazones. Under heating, an addition of the hydrazone onto the central carbon of the ketenimine takes place, giving rise to various acetamidohydrazides.