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Base-Mediated Generation of Ketenimines from Ynamides: Addition of Hydrazones to Give Acetimidohydrazides

preprint
submitted on 05.03.2021, 21:49 and posted on 08.03.2021, 13:18 by Capucine Mahe, Agathe C. A. D’Hollander, Kevin Cariou
Under basic conditions, N-arylketenimines were generated in situ from N-Boc ynamides and reacted with hydrazones. Under heating, an addition of the hydrazone onto the central carbon of the ketenimine takes place, giving rise to various acetamidohydrazides.

Funding

LERMIT, grant ANR-10-LABX-33 under the program Investissements d’Avenir ANR-11-IDEX-0003-01

History

Email Address of Submitting Author

kevin.cariou@cnrs.fr

Institution

Chimie ParisTech, PSL University, CNRS Institute of Chemistry for Life and Health Sciences, Paris

Country

France

ORCID For Submitting Author

0000-0002-5854-9632

Declaration of Conflict of Interest

There is no conflict of interest

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