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Aza-BODIPY Platform: Towards an Efficient Water-Soluble Bimodal Imaging Probe for MRI and Near-Infrared Fluorescence

preprint
submitted on 05.12.2019, 12:01 and posted on 19.12.2019, 19:57 by Oceane Flores, Jacques Pliquett, Laura Abad Galan, Robin Lescure, Franck Denat, Olivier Maury, Agnès Pallier, Pierre-Simon Bellaye, Bertrand Collin, Sandra Même, Celia S. Bonnet, Ewen Bodio, Christine Goze

In this study, an original aza-BODIPY system comprising two Gd3+ complexes has been designed and synthesized for magnetic resonance imaging/optical imaging application, by functionalization of the boron center. This strategy enabled to obtain a positively-charged bimodal probe, which displays an increased water-solubility, optimized photophysical properties in the near-infrared region, and very promising relaxometric properties. The absorption and emission wavelengths are 705 and 741 nm respectively, with a quantum yield of around 10 % in aqueous media. Moreover, the system does not produce singlet oxygen upon excitation, which would be toxic for tissues. The relaxivity obtained is high at intermediate fields (16.1 mM-1.s-1 at 20 MHz and 310 K) and competes with that of bigger or more rigid systems. A full relaxometric and 17O NMR study and fitting of the data using the Lipari-Szabo approach showed that this high relaxivity can be explained by the size of the system and the presence of some small aggregates. These optimized photophysical and relaxometric properties highlight the potential use of such systems for future bimodal imaging studies.

History

Email Address of Submitting Author

laura.abad-galan@ens-lyon.fr

Institution

ENS-Lyon

Country

France

ORCID For Submitting Author

0000-0001-6226-0850

Declaration of Conflict of Interest

No conflict of interest

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