Automated Stirring Device for Continuous Stirring While Sampling in Liquid Chromatography Systems

A device is presented, which enables continuous stirring of samples whilst inside an ultra-performance liquid chromatography system. Utilizing standard magnetic stirring bars that fit standard vials, the device allows for the automation of experimental setups that require stirring. The device is designed such that it can replace the standard sample holder and fits in its place, while being battery operated. The use of 3D printing and commercially available parts enables low-effort and low-cost device production, as well as easy modifications. Various tests were performed by following the kinetics of a dynamic combinatorial library that is known for exhibiting self-replication under mechanical agitation, via fiber growth-breakage mechanism. Design files and schematics are available.