These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
StirringDevice-PrePrint-17Jun20.pdf (323.7 kB)

Automated Stirring Device for Continuous Stirring While Sampling in Liquid Chromatography Systems

submitted on 24.06.2020, 05:24 and posted on 26.06.2020, 07:59 by Omer Markovitch, Jim Ottelé, Obe Veldman, Sijbren Otto
A device is presented, which enables continuous stirring of samples whilst inside an ultra-performance liquid chromatography system. Utilizing standard magnetic stirring bars that fit standard vials, the device allows for the automation of experimental setups that require stirring. The device is designed such that it can replace the standard sample holder and fits in its place, while being battery operated. The use of 3D printing and commercially available parts enables low-effort and low-cost device production, as well as easy modifications. Various tests were performed by following the kinetics of a dynamic combinatorial library that is known for exhibiting self-replication under mechanical agitation, via fiber growth-breakage mechanism. Design files and schematics are available.


O.M. is funded through the NWA StartImpuls. This work has been funded by the ERC, the NWO and the Dutch Ministry of Education, Culture and Science.


Email Address of Submitting Author


University of Groningen


The Netherlands

ORCID For Submitting Author


Declaration of Conflict of Interest

O.V. was hired for several assignments during the development of the device.