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Asymmetric Chemoenzymatic Synthesis of Podophyllotoxin and Related Aryltetralin Lignans

preprint
submitted on 03.04.2019 and posted on 04.04.2019 by Jian Li, Xiao Zhang, Hans Renata
We report a concise chemoenzymatic synthesis of podophyllotoxin. Highlights of the synthesis include the use of enzymatic oxidative coupling to generate the tetracyclic core of the natural product, and late stage chemical oxidation to install the requisite secondary alcohol.

Funding

GM128895

History

Email Address of Submitting Author

hrenata@scripps.edu

Institution

The Scripps Research Institute

Country

USA

ORCID For Submitting Author

0000-0003-2468-2328

Declaration of Conflict of Interest

No conflict of interest

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