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Assessing Vesicular Monoamine Transport and Toxicity Using Fluorescent False Neurotransmitters
preprintsubmitted on 27.08.2020, 14:13 and posted on 28.08.2020, 07:33 by Carlie A. Hoffman, Meghan Bucher, Joshua M. Bradner, Lauren Jonas, Kenny Igarza, Gary W. Miller
This manuscript outlines a high-throughput 96-well plate assay to measure the vesicular uptake of the false fluorescent neurotransmitter FFN206 by the vesicular monoamine transporter 2 (VMAT2) in near real-time and following pharmacological and environmental toxicant exposure in HEK293 cells.