ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Arene Dearomatization_Stephenson_ChemRxiv_Final V2.pdf (774.6 kB)
0/0

Arene Dearomatization via a Catalytic N-Centered Radical Cascade Reaction

preprint
revised on 22.04.2020 and posted on 23.04.2020 by Rory McAtee, Efrey Noten, Corey Stephenson

This photocatalysis methodology leverages N-centered radicals, from easily prepared γ,δ-unsaturated N-arylsulfonyl enamides, to initiate a carboamination/dearomatization cascade reaction that generates stereodefined 1,4-cyclohexadiene-fused sultams. This unique reactivity serves as a general platform for arene dearomatization and the fused heterocyclic products are viewed as valuable building blocks for drug discovery programs.

Funding

NIH GM127774

NSF-GRFP 1256260

History

Email Address of Submitting Author

rorycm@umich.edu

Institution

University of Michigan

Country

United States

ORCID For Submitting Author

0000-0003-4879-3583

Declaration of Conflict of Interest

no conflicts of interest.

Exports