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Application of Amino Transaminases in a Disperse System for the Biotransformation of Hydrophobic Substrates

preprint
submitted on 30.10.2019, 19:09 and posted on 05.11.2019, 23:40 by Andrea Fiorati, Per Berglund, maria humble, Davide Tessaro
The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting in a combination of a low polarity solvent (e.g. isooctane or MTBE), a non-ionic surfactant and a minimal amount of water. In these conditions, good conversions are achieved, often coupled with a superior stereoselectivity if compared with the corresponding chemical reductive amination. An array of synthetically useful 4-substituted aminocyclohexanes was consequentially synthesized and stereochemically characterized.

History

Email Address of Submitting Author

davide.tessaro@polimi.it

Institution

Politecnico di Milano

Country

Italy

ORCID For Submitting Author

0000-0002-3106-0247

Declaration of Conflict of Interest

No conflict of interest to declare

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