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Application of Amino Transaminases in a Disperse System for the Biotransformation of Hydrophobic Substrates

preprint
submitted on 30.10.2019 and posted on 05.11.2019 by Andrea Fiorati, Per Berglund, maria humble, Davide Tessaro
The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting in a combination of a low polarity solvent (e.g. isooctane or MTBE), a non-ionic surfactant and a minimal amount of water. In these conditions, good conversions are achieved, often coupled with a superior stereoselectivity if compared with the corresponding chemical reductive amination. An array of synthetically useful 4-substituted aminocyclohexanes was consequentially synthesized and stereochemically characterized.

History

Email Address of Submitting Author

davide.tessaro@polimi.it

Institution

Politecnico di Milano

Country

Italy

ORCID For Submitting Author

0000-0002-3106-0247

Declaration of Conflict of Interest

No conflict of interest to declare

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