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Antiplasmodial Biodereplication Based on Highly Efficient Methods

preprint
submitted on 09.02.2020 and posted on 14.02.2020 by Pedro Vásquez-Ocmín, Jean-François Gallard, Anne-Cécile Van Baelen, Karine Leblanc, Sandrine Cojean, Elizabeth Mouray, Philippe Grellier, Carlos Amasifuén, Guillaume Bernadat, Laurent Evanno, Bruno Figadère, Alexandre Maciuk
We propose a biodereplication method using mass spectrometry and combining the classical dereplication approach with the predominant mechanism of action of antimalarial drugs. The method encompasses a biomimetic heme binding assay (heme adducts detection by MS), molecular networking for quick data mining, CPC for extract fractionation and compounds isolation and in silico modeling of heme adducts by molecular docking.

Funding

Consejo de Ciencia y Tecnología del Perú (CONCYTEC) (Council for science and technology of Peru) (299 - 2014 -FONDECYT) for the Ph.D. scholarship (PGVO)

History

Email Address of Submitting Author

vasco2224@gmail.com

Institution

Paris Sud University

Country

France

ORCID For Submitting Author

0000-0003-0705-2762

Declaration of Conflict of Interest

The authors declare no competing financial interest

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