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Guanosine NHC.pdf (921.38 kB)

Anti-proliferative Activity of N-Heterocyclic Carbenes Derived from Guanosine

preprint
submitted on 23.03.2018 and posted on 26.03.2018 by Maria Inês Leitão, Federico Herrera, Ana Petronilho
Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbene derived from Guanosine are synthesized via oxidative addition. Cytotoxicity of the compounds is evaluated with human embryonic kidney (HEK293) cells, glioblastoma (U251) cervical cancer (HeLa) cells and prostate cancer (PC3) cells. Compounds 2a, 2b and 3a are highly selective for glioblastoma.

History

Email Address of Submitting Author

ana.petronilho@itqb.unl.pt

Institution

ITQB-NOVA

Country

Portugal

ORCID For Submitting Author

0000-0002-3296-1522

Declaration of Conflict of Interest

No conflict of interest

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