Anti-proliferative Activity of N-Heterocyclic Carbenes Derived from Guanosine

Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbene derived from Guanosine are synthesized via oxidative addition. Cytotoxicity of the compounds is evaluated with human embryonic kidney (HEK293) cells, glioblastoma (U251) cervical cancer (HeLa) cells and prostate cancer (PC3) cells. Compounds 2a, 2b and 3a are highly selective for glioblastoma.