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Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid, Mild and Practical Way to Access Functionalised Orthoesters

preprint
submitted on 16.04.2020, 16:34 and posted on 20.04.2020, 08:45 by Anthony Garcia, Matthew Leech, Alessia Petti, Camille Denis, Iain C. A. Goodall, Adrian Dobbs, Kevin Lam
A new electrochemical methodology has been developed for the preparation of a wide variety of functionalised orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalised orthoesters from simple and readily available starting materials.

Funding

EPSRC Grant EP/S017097/1

European Union’s Horizon 2020 – Marie Skłodowska -Curie Grant 801604

History

Email Address of Submitting Author

k.lam@greenwich.ac.uk

Institution

University of Greenwich

Country

United Kingdom

ORCID For Submitting Author

0000-0003-1481-9212

Declaration of Conflict of Interest

None

Exports