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Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid, Mild and Practical Way to Access Functionalised Orthoesters
preprintsubmitted on 16.04.2020, 16:34 and posted on 20.04.2020, 08:45 by Anthony Garcia, Matthew Leech, Alessia Petti, Camille Denis, Iain C. A. Goodall, Adrian Dobbs, Kevin Lam
A new electrochemical methodology has been developed for the preparation of a wide variety of functionalised orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalised orthoesters from simple and readily available starting materials.