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Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid, Mild and Practical Way to Access Functionalised Orthoesters

preprint
submitted on 16.04.2020 and posted on 20.04.2020 by Anthony Garcia, Matthew Leech, Alessia Petti, Camille Denis, Iain C. A. Goodall, Adrian Dobbs, Kevin Lam
A new electrochemical methodology has been developed for the preparation of a wide variety of functionalised orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalised orthoesters from simple and readily available starting materials.

Funding

EPSRC Grant EP/S017097/1

European Union’s Horizon 2020 – Marie Skłodowska -Curie Grant 801604

History

Email Address of Submitting Author

k.lam@greenwich.ac.uk

Institution

University of Greenwich

Country

United Kingdom

ORCID For Submitting Author

0000-0003-1481-9212

Declaration of Conflict of Interest

None

Exports