ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
2 files

An In-Depth Analysis Approach Enabling Precision Single Chain Nanoparticle Design

preprint
submitted on 24.08.2020, 12:35 and posted on 25.08.2020, 04:49 by Johanna Engelke, Bryan T. Tuten, Ralf Schweins, Hartmut Komber, Leonie Barner, Laura Plüschke, Christopher Barner-Kowollik, Albena Lederer
The formation of single chain nanoparticles (SCNPs) is typically characterized by a shift towards higher elution volumes in SEC due to size decrease upon folding. However, a step-change in SCNP analysis is required for understanding of the nature of intramolecular SCNP folding. Herein, we exploit a unique combination of SANS, 19F NMR spectroscopy, and multidetection SEC to generate a systematic view of the folded morphology of poly(butyl acrylate) based-SCNPs as a function of their reactive group density and molar mass. In addition to detailed morphological insights, we establish that the primary factor dictating the compaction of SCNPs is their reactive group density, which is ineffective below 5 mol%, reaching maximum compaction close to 30 mol%. Above 20 kDa the molar mass of the precursor polymers has a minor impact on how an SCNP compacts.

Funding

Australian Research Council (ARC)

SasView application: NSF award DMR-0520547; EU project SINE2020

ILL project doi:10.5291/ILL-DATA.9-11-1908

History

Email Address of Submitting Author

lederer@ipfdd.de

Institution

Leibniz-Institiut für Polymerforschung Dresden

Country

Germany

ORCID For Submitting Author

0000-0002-1760-6426

Declaration of Conflict of Interest

No conflict of interest.

Exports