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An In-Depth Analysis Approach Enabling Precision Single Chain Nanoparticle Design

submitted on 24.08.2020, 12:35 and posted on 25.08.2020, 04:49 by Johanna Engelke, Bryan T. Tuten, Ralf Schweins, Hartmut Komber, Leonie Barner, Laura Plüschke, Christopher Barner-Kowollik, Albena Lederer
The formation of single chain nanoparticles (SCNPs) is typically characterized by a shift towards higher elution volumes in SEC due to size decrease upon folding. However, a step-change in SCNP analysis is required for understanding of the nature of intramolecular SCNP folding. Herein, we exploit a unique combination of SANS, 19F NMR spectroscopy, and multidetection SEC to generate a systematic view of the folded morphology of poly(butyl acrylate) based-SCNPs as a function of their reactive group density and molar mass. In addition to detailed morphological insights, we establish that the primary factor dictating the compaction of SCNPs is their reactive group density, which is ineffective below 5 mol%, reaching maximum compaction close to 30 mol%. Above 20 kDa the molar mass of the precursor polymers has a minor impact on how an SCNP compacts.


Australian Research Council (ARC)

SasView application: NSF award DMR-0520547; EU project SINE2020

ILL project doi:10.5291/ILL-DATA.9-11-1908


Email Address of Submitting Author


Leibniz-Institiut für Polymerforschung Dresden



ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest.