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An EPR Strategy for Bio-responsive Fluorescence Guided Surgery with Simulation of the Benefit for Imaging

preprint
submitted on 04.12.2019 and posted on 12.12.2019 by Harrison C. Daly, Emer Conroy, Mihai Todor, Dan Wu, William M Gallagher, Donal O'Shea

A successful matching of a PEG group size with the EPR effect for an off-to-on responsive NIR-fluorophore conjugate has been accomplished which allows two distinct in vivo tumor imaging periods, the first being the switch on during the initial tumor uptake via enhanced permeability into the ROI (as background is suppressed) and a second, later, due to enhanced retention within the tumor. Software simulation (https://mihaitodor.github.io/particle_simulation/index.html), synthetic chemistry, with in vitro and in vivo imaging have been synergistically employed to identify the optimal PEG-fluorophore conjugate for in vivo tumor imaging.

Funding

Project Ireland 2040 Disruptive Technology Innovation Fund

Science Foundation Ireland grant number 11/PI/1071(T)

Irish Cancer Society Collaborative Cancer Research Centre Breast-Predict.

History

Email Address of Submitting Author

donalfoshea@rcsi.ie

Institution

RCSI

Country

Ireland

ORCID For Submitting Author

0000-0003-0594-4193

Declaration of Conflict of Interest

DOS declares the following competing financial interest. Patents have been filed on BF2-azadipyrromethene based NIR fluorophores (EP2493898 and US8907107) in which he has a financial interest.

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