Adrenergic Modulation with Photochromic Ligands

28 April 2020, Version 1

Abstract

Adrenoceptors are ubiquitous and regulate heart and respiratory rate, digestion, metabolism, and vascular tone. They can be activated or blocked with adrenergic drugs, but systemic administration causes broad adverse effects. We have developed photochromic ligands (adrenoswitches) to switch on and off adrenoceptor activity on demand at selected locations. Their pharmacology, photochromism, bioavailability and lack of toxicity allow photomodulating adrenergic signalling, as demonstrated by controlling locomotion in zebrafish and pupillary responses in blind mice.

Keywords

adrenergic
neuromodulation
photopharmacology
azoheteroarene
photochromic ligans
pupil photoregulation

Supplementary materials

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Adrenergic modulation with photochromic ligands (SI)
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