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Accelerated Saddle Point Refinement Through Full Exploitation of Partial Hessian Diagonalization

submitted on 29.08.2019, 19:05 and posted on 30.08.2019, 15:48 by Eric Hermes, Khachik Sargsyan, Habib Najm, Judit Zádor
Identification and refinement of first order saddle point (FOSP) structures on the potential energy surface (PES) of chemical systems is a computational bottleneck in the characterization of reaction pathways. Leading FOSP refinement strategies require calculation of the full Hessian matrix, which is not feasible for larger systems such as those encountered in heterogeneous catalysis. For these systems, the standard approach to FOSP refinement involves iterative diagonalization of the Hessian, but this comes at the cost of longer refinement trajectories due to the lack of accurate curvature information. We present a method for incorporating information obtained by an iterative diagonalization algorithm into the construction of an approximate Hessian matrix that accelerates FOSP refinement. We measure the performance of our method with two established FOSP refinement benchmarks and find a 50% reduction on average in the number of gradient evaluations required to converge to a FOSP for one benchmark, and a 25% reduction on average for the second benchmark.


U.S. Department of Energy, Office of Science, Basic Energy Sciences, Chemical Sciences, Geosciences and Biosciences Division, as part of the Computational Chemistry Sciences Program (Award Number: 0000232253)


Email Address of Submitting Author


Sandia National Laboratories


United States

ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest declared

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in Journal of Chemical Theory and Computation