Absolute Autocatalytic Amplification Under Heterogenous Conditions Involving Subsequent Hydride Transfer and Hemiacetal Intermediate.

Absolute asymmetric amplification is observed for pyridine alkanol by reaction with iPr2Zn vapor under heterogenous conditions. Beside the chiral alkanol, formation of a chiral ester is observed and identified as a subsequent Claisen-Tishchenko product of a hemiacetal intermediate during a Soai absolute amplification.