A biomimetic cerium-based biosensor for the direct visual detection of phosphate under physiological conditions

15 April 2019, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An indicator displacement assay (IDA) was used to probe phosphate ions in acqueous medium at neutral pH using a dinuclear cerium based complex [Ce2(HXTA)]3+. The homoleptic complex can be used to detect phosphate ions in micromolar concentrations either spectrophotometrically or with the naked-eye. To our knowledge, this is the biomimetic detection system with the highest affinity known to date for selective, naked-eye based phosphate recognition under physiological conditions.

Keywords

HXTA
pyrocathecol violet
phosphate
indicator displacement assay
cerium

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