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A Mn(II)-based zinc-sensitive MRI contrast agent, Mn(PyC3A)-BPEN, was prepared and
characterized and the agent was used in imaging experiments to detect
glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinetic
stability tests showed that Mn(PyC3A-BPEN) has superior kinetic inertness
compared to Gd(DTPA), is less susceptible to transmetallation in the presence
of excess Zn2+
ions, and less susceptible to transchelation by albumin. In comparison with other gadolinium-based
zinc sensors bearing a single zinc binding moiety, Mn(PyC3A-BPEN) appears to be a reliable alternative for imaging b-cell function in the pancreas and
glucose-stimulated zinc secretion from prostate cells.