ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
3 files

A Sweet Galactose Transfer – Metabolic Oligosaccharide Engineering as a Tool to Study Glycans in Plasmodium Infection

preprint
submitted on 01.11.2019, 10:38 and posted on 07.11.2019, 21:51 by Annabel Kitowski, Gonçalo Bernardes
The use of artificial galactose derivatives and labelling through iEDDA reaction in the liver stage of Plasmodium infection showed increased uptake in infected hepatic cells, through participation of GLUT1 transporters. Furthermore, unprotected derivatives are transferred from the mosquito host to the Plasmodium berghei parasite. This strategy has the potential to provide new insights into Plasmodium glycobiology.

Funding

Marie Skłodowska-Curie Actions - GA675671

Royal Society (URF\R\180019)

FCT Portugal (iFCT IF/00624/2015)

History

Email Address of Submitting Author

gb453@cam.ac.uk

Institution

University of Cambridge

Country

United Kingdom

ORCID For Submitting Author

0000-0001-6594-8917

Declaration of Conflict of Interest

The authors declare no conflict of interests.

Exports