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Luis 2019 chemrxiv.pdf (255.92 kB)
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A Strategy for Thioamide Incorporation During Fmoc Solid-Phase Peptide Synthesis with Robust Stereochemical Integrity

preprint
submitted on 30.05.2019 and posted on 31.05.2019 by luis camacho III, Bryan J. Lampkin, Brett VanVeller
We describe a method to protect the sensitive stereochemistry of the thioamide—in analogy to the protection of the functional groups of amino acid side chains—in order to preserve the thioamide moiety during peptide elongation.

History

Email Address of Submitting Author

bvv@iastate.edu

Institution

Iowa State University

Country

USA

ORCID For Submitting Author

0000-0002-3792-0308

Declaration of Conflict of Interest

The authors declare no conflicts of interest

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