A Strategy for Thioamide Incorporation During Fmoc Solid-Phase Peptide Synthesis with Robust Stereochemical Integrity

31 May 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We describe a method to protect the sensitive stereochemistry of the thioamide—in analogy to the protection of the functional groups of amino acid side chains—in order to preserve the thioamide moiety during peptide elongation.

Keywords

thioamide
thioimidate
SPPS
peptide
racemize
epimerize

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