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A Prelude to Biogermylene Chemistry

preprint
submitted on 19.06.2020, 17:18 and posted on 29.06.2020, 09:14 by Pritam Mahawar,, Mishi Kaushal Wasson, Mahendra Kumar Sharma, Chandan Kumar Jha, Goutam Mukherjee, Perumal Vivekanandan, Selvarajan Nagendran

Abstract: The biological applications of germylenes remain an unconceivable domain owing to their unstable nature. We report the isolation of air, water, and culture-medium stable germylene DPMGeOH (3) and its potential biological application (DPM = dipyrromethene ligand). Compound 3 exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound 3 on normal epithelial cells is minimal and is similar to that of the currently used anti-cancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low-valent main group chemistry.

Funding

EMR/2017/005519

(SR/ FST/CSII-027/2014

SR/FST/CS-1-195/2008

History

Email Address of Submitting Author

sisn@chemistry.iitd.ac.in

Institution

Indian Institute of technology Delhi

Country

India

ORCID For Submitting Author

0000-0003-1053-8878

Declaration of Conflict of Interest

The authors declare no competing financial interest.

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