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A Prelude to Biogermylene Chemistry

preprint
submitted on 19.06.2020 and posted on 29.06.2020 by Pritam Mahawar,, Mishi Kaushal Wasson, Mahendra Kumar Sharma, Chandan Kumar Jha, Goutam Mukherjee, Perumal Vivekanandan, Selvarajan Nagendran

Abstract: The biological applications of germylenes remain an unconceivable domain owing to their unstable nature. We report the isolation of air, water, and culture-medium stable germylene DPMGeOH (3) and its potential biological application (DPM = dipyrromethene ligand). Compound 3 exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound 3 on normal epithelial cells is minimal and is similar to that of the currently used anti-cancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low-valent main group chemistry.

Funding

EMR/2017/005519

(SR/ FST/CSII-027/2014

SR/FST/CS-1-195/2008

History

Email Address of Submitting Author

sisn@chemistry.iitd.ac.in

Institution

Indian Institute of technology Delhi

Country

India

ORCID For Submitting Author

0000-0003-1053-8878

Declaration of Conflict of Interest

The authors declare no competing financial interest.

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