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GendronEtAl_NKR_ChemRxiv.pdf (390.34 kB)

A Practical Iron-Based Newman-Kwart Rearrangement Under Oxidative Conditions

submitted on 23.10.2019, 12:15 and posted on 29.10.2019, 20:57 by Thibault Gendron, Raul Pereira, Hafsa Yusuf Abdi, Timothy Witney, Erik Arstad
Herein, we report that iron(II)/ammonium persulfate in aqueous acetonitrile mediates the Newman-Kwart rearrangement of O-aryl carbamothioates. Electron-rich substrates react rapidly under moderate heating to afford the rearranged products in excellent yields. The mild conditions, rapid reaction rates, and suitability for scale up offer immediate practical benefits to access functionalised thiophenols.


Detecting tumour resistance to treatment with positron emission tomography.

Wellcome Trust

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CRUK & EPSRC C1519/A16463

CRUK & EPSRC C2536/A10337

NIHR University College London Hospitals Biomedical Research Centre

NIHR Central Commissioning Facility

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Email Address of Submitting Author


King's College London


United Kingdom

ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest

Version Notes

Initial submission


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in Organic Letters

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