These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
A Platform for Alkene Carbofunctionalization with Diverse Nucleophiles
preprintsubmitted on 25.03.2021, 16:01 and posted on 26.03.2021, 10:21 by Travis Buchanan, Samuel Gockel, Alexander Veatch, Ya-Nong Wang, Kami Hull
A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented. A range of substituted alkenes are functionalized with α-bromo carbonyl electrophiles and nitrogen, oxygen, and carbon nucleophiles. Mechanistic findings support the intermediacy of a cyclic oxocarbenium ion.