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A Platform for Alkene Carbofunctionalization with Diverse Nucleophiles

preprint
submitted on 25.03.2021, 16:01 and posted on 26.03.2021, 10:21 by Travis Buchanan, Samuel Gockel, Alexander Veatch, Ya-Nong Wang, Kami Hull
A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented. A range of substituted alkenes are functionalized with α-bromo carbonyl electrophiles and nitrogen, oxygen, and carbon nucleophiles. Mechanistic findings support the intermediacy of a cyclic oxocarbenium ion.

Funding

NIH NIGMS

The Welch Foundation

Novartis

Eli Lilly and Co.

History

Email Address of Submitting Author

travis.buchanan@austin.utexas.edu

Institution

University of Texas at Austin

Country

United States

ORCID For Submitting Author

0000-0001-9038-9790

Declaration of Conflict of Interest

The authors declare no competing financial interests.

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