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A Pathogen Mimetic Molecule Induces Highly Amplified Synergistic Immune Activation to Vaccination via Activation of Multiple Signaling Pathways
preprintsubmitted on 16.10.2020, 20:02 and posted on 19.10.2020, 10:26 by naorem nihesh, Saikat Manna, Bradley Studnitzer, Jingjing Shen, Aaron Esser-Kahn
We developed a small-molecule trimeric PRR agonist-based adjuvant inspired by the stimulation pattern of a pathogen. This molecule generated by covalently linking TLR2/6 agonist, NOD2 agonist, and NLRP3 inflammasome activator, stimulates multiple subfamilies of PRRs in a spatially defined manner resulting in an amplified innate immune response in vitro. Moreover, it elicits both stronger humoral and cellular immune responses in vivo.