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A Novel Enzyme-Triggered Domino Reaction Producing Fluorescent Quinoxalin-2(1H)-One-Based Heterocycles

preprint
submitted on 06.07.2020 and posted on 07.07.2020 by Garance Dejouy, Kevin Renault, Quentin Bonnin, Arnaud Chevalier, Cédric Michaudet, Michel Picquet, Ibai E. Valverde, Anthony ROMIEU
A simple and effective biocompatible domino reaction triggered by a model protease and leading to formation of strongly fluorescent quinoxalin-2(1H)-one N-heterocycles is described. Some positive attributes including versatility and ability to provide outstanding fluorescence "OFF-ON" responses were revealed by this work. They open the way for practical applications of this novel type of "covalent-assembly" based fluorescent probes in the fields of sensing and bioimaging.

Funding

Butyrylcholinesterase-based fluorescent and/or colorimetric detection of organophosphorus nerve agents – DetectOP_BChE

Agence Nationale de la Recherche

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A luminogenic real-time detection system for monitoring enzymatic manufacturing of oligonucleotides – LuminoManufacOligo

Agence Nationale de la Recherche

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PO FEDER-FSE Bourgogne 2014/2020

History

Email Address of Submitting Author

kevin.ren4ult@gmail.com

Institution

Univ. Bourgogne Franche-Comté

Country

France

ORCID For Submitting Author

0000-0003-4427-8146

Declaration of Conflict of Interest

No conflict of interest

Version Notes

Version 1 06.07.2020

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