These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Urat-IOCh_01.pdf (77.11 kB)

A New Perspective for Litholysis? Influence of Amines on the Solubility of Kindney Stones in Vitro

submitted on 05.10.2020, 16:02 and posted on 06.10.2020, 09:13 by Bogdan Nataly, Volodymyr Bilobrov, Anatoliy Matviyenko
It was shown that amines increase the equilibrium solubility of uric acid kidney
stones substantially and stabilize the process of litholysis in due course. However, these amines compete with ammonium in salt formation. Imidazole and triethanolamine are stabilize of uric acid solubility when [NH 4+ ] < 20 mM, and piperazine promotes the dissolution of uric acid if [NH 4+ ] > 46 mM. In salt solutions simulating complete cationic composition of
human urine, solubility of uric acid is practically the same for the systems with imidazole and piperazine and it is some lower for triethanolamine containing system


was supported by NAS of Ukraine


Email Address of Submitting Author


Institute of Organic Chemistry of National Academy of Sciences of Ukraine



ORCID For Submitting Author


Declaration of Conflict of Interest

no conflict of interests


Logo branding