A Molecular Logic Gate for the Naked-Eye Detection of Gluthatione or Pyrophosphate with a Nickel Based Bio-Sensor
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An inorganic water soluble Ni(II) complex offers a molecular logic gate for the naked-eye detection of pyrophosphate versus thiol derivatives. Pyrocathecol coordinated to nickel performs a thiol-michael addition click reaction in the presence of thiol derivativs whereas pyrophosphate allows a displacement of the indicator PCV leading to an indicator displacement assay.