ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
2 files

A Modular, Argon-Driven Flow Platform for Natural Product Synthesis and Late-Stage Transformations

preprint
submitted on 20.11.2020, 15:16 and posted on 23.11.2020, 12:27 by Merlin Kleoff, Johannes Schwan, Mathias Christmann, Philipp Heretsch
A modular flow platform for the synthesis of natural products and their analogs was designed. To access different reaction setups with a maximum of flexibility, interchangeable 3D-printed components serve as backbone. By switching from conventional liquid- to gas-driven flow, reagent and solvent waste is minimized which translates into an advantageous sustainability and economy profile. To enable inert conditions, practical “Schlenk-in-flow” techniques for the safe handling of oxygen- and moisture sensitive reagents were developed. Adopting these techniques, reproducible transformations in natural product synthesis were achieved.

Funding

Boehringer Ingelheim Stiftung

History

Email Address of Submitting Author

philipp.heretsch@fu-berlin.de

Institution

Freie Universität Berlin

Country

Germany

ORCID For Submitting Author

0000-0002-9967-3541

Declaration of Conflict of Interest

none declared

Exports

ChemRxiv

Exports