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A Method for the Growth of Uniform Silica Shells on Different Size and Morphology Upconversion Nanoparticles

submitted on 16.02.2021, 16:00 and posted on 17.02.2021, 13:05 by Elena Ureña-Horno, Maria Eleni Kyriazi, Antonios Kanaras
Lanthanide-doped upconversion nanoparticles have emerged as attractive candidates for biomedical applications. This is due to their excitation and emission wavelengths, which lay the foundation for deeper penetration depth into biological tissue, higher resolution due to reduced scattering and improved imaging contrast as a result of a decrease in autofluorescence background. Usually, their encapsulation within a biocompatible silica shell is a requirement for their dispersion within complex media or for further functionalization of the upconversion nanoparticle surface. However, the creation of a silica shell around upconversion nanoparticles can be often challenging, many times resulting in partial silica coating or nanoparticle aggregation, as well as the production of a large number of silica particles as a side product. In this work we demonstrate a method to accurately predict the experimental conditions required to form a high yield of silica-coated upconversion nanoparticles, regardless of their shape and size.


Development of a graphene oxide nanosensor for fast detection of mRNA-related sequences in crops.

Biotechnology and Biological Sciences Research Council

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University of Southampton


United Kingdom

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