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A Metal-Free Facile Construction of C(sp3) –CF3 Bond: Trifluoromethylation of Hydrazones with Togni’s Reagent under Mild Conditions
preprintsubmitted on 17.06.2019, 05:41 and posted on 18.06.2019, 14:53 by Zhen Luo, Xinlong Han, Huiying Zeng, Chao-Jun Li
A metal-free trifluoromethylation of hydrazones with Togni’s reagent under mild conditions was developed. Various functional groups including ester, methoxy, dimethoxy, nitro, halogen and heterocyclic compounds were tolerated. This simple and green strategy provides a practical tool to construct C(sp3) –CF3 bonds