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submitted on 17.06.2019 and posted on 18.06.2019by Zhen Luo, Xinlong Han, Huiying Zeng, Chao-Jun Li
A metal-free trifluoromethylation of hydrazones with
Togni’s reagent under mild conditions was developed. Various functional groups including ester, methoxy, dimethoxy, nitro, halogen and heterocyclic compounds were tolerated. This
simple and green strategy provides a practical tool to construct C(sp3) –CF3