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A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light

preprint
submitted on 05.09.2018 and posted on 06.09.2018 by Kaid Harper, Eric Moschetta, shailendra Bordawekar, steven wittenberger
Visible light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multi-kilogram production. We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high intensity laser to drive photochemical reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer-Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochemical reactions.

History

Email Address of Submitting Author

kaid.harper@abbvie.com

Institution

AbbVie

Country

USA

ORCID For Submitting Author

0000-0003-3894-4851

Declaration of Conflict of Interest

Authors declare no conflicts of interest

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