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A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light

preprint
submitted on 05.09.2018, 18:07 and posted on 06.09.2018, 12:55 by Kaid Harper, Eric Moschetta, shailendra Bordawekar, steven wittenberger
Visible light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multi-kilogram production. We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high intensity laser to drive photochemical reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer-Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochemical reactions.

History

Email Address of Submitting Author

kaid.harper@abbvie.com

Institution

AbbVie

Country

USA

ORCID For Submitting Author

0000-0003-3894-4851

Declaration of Conflict of Interest

Authors declare no conflicts of interest

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