These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
2 files

A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light

submitted on 05.09.2018, 18:07 and posted on 06.09.2018, 12:55 by Kaid Harper, Eric Moschetta, shailendra Bordawekar, steven wittenberger
Visible light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multi-kilogram production. We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high intensity laser to drive photochemical reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer-Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochemical reactions.


Email Address of Submitting Author





ORCID For Submitting Author


Declaration of Conflict of Interest

Authors declare no conflicts of interest