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A General Carbonyl Alkylative Amination Process for Tertiary Amine Synthesis

preprint
submitted on 23.10.2019, 11:39 and posted on 25.10.2019, 19:15 by Roopender Kumar, Nils Floden, William G. Whitehurst, Matthew Gaunt
We report a practical and general solution to this long-standing synthetic challenge can be accomplished by addition of alkyl radicals to all alkyl-iminium ions. The process is mediated by the action of visible light and a simple silane reducing agent, establishing a chain process that permits the combination of an extremely wide range of aldehydes and secondary amines with alkyl halides.

Funding

Swiss National Science Foundation

EPSRC

Gates Cambridge Trust

The Royal Society (Wolfson Merit Award)

History

Email Address of Submitting Author

mjg32@cam.ac.uk

Institution

University of Cambridge

Country

United Kingdom

ORCID For Submitting Author

0000-0002-7214-608X

Declaration of Conflict of Interest

no conflict of interest

Version Notes

SI file added to address potentially poor resolution in NMR spectra as a result of file compression

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