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A General Carbonyl Alkylative Amination Process for Tertiary Amine Synthesis
preprintsubmitted on 23.10.2019, 11:39 and posted on 25.10.2019, 19:15 by Roopender Kumar, Nils Floden, William G. Whitehurst, Matthew Gaunt
We report a practical and general solution to this long-standing synthetic challenge can be accomplished by addition of alkyl radicals to all alkyl-iminium ions. The process is mediated by the action of visible light and a simple silane reducing agent, establishing a chain process that permits the combination of an extremely wide range of aldehydes and secondary amines with alkyl halides.