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A Dinuclear Copper Based Artificial Metalloenzyme for the Kinetic Resolution of Adrenalin
preprintsubmitted on 17.04.2020, 10:07 and posted on 20.04.2020, 10:47 by Thibaud Rossel
Incorporation of a copper catalyst within carbonic anhydrase affords artificial metalloenzyme for the oxidation of catechols in aqueous solution at physiological pH. Optimization of the performance can be achieved either by chemical or genetic means. In addition, a model of enzyme/inhibitor is proposed and discussed.