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A Di Copper Peptidyl Complex Mimics Catalase Activity in HeLa HyPer Cells

preprint
submitted on 11.11.2020, 22:30 and posted on 12.11.2020, 13:31 by Koudedja Coulibaly, Marion Thauvin, Adyn Melenbacher, Clara testard, Evangelia Trigoni, Amandine Vincent, Martin J. Stillman, Sophie Vriz, Clotilde Policar, Nicolas DELSUC
In this manuscript, we describe the implementation of a combinatorial apporach to synthesize a library of copper complexes, associated with an activity-based screening to discover the first peptidyl di copper complex mimicking CAT redox chemistry. The selected dinuclear complex was studied in detail and characterized for its CAT activity in vitro and in cells. Very interestingly, despite moderate intrinsic catalysis constant, this complex was efficacious in a cellular assay.

Funding

ANR16-CE07-0025-01

NSERC Discovery Grant 2020-06545

History

Email Address of Submitting Author

nicolas.delsuc@ens.psl.eu

Institution

Laboratoire des biomolécules, LBM, ENS, PSL University, Sorbonne Université, CNRS

Country

France

ORCID For Submitting Author

0000-0001-5570-8311

Declaration of Conflict of Interest

no conflict of interest

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