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A Di Copper Peptidyl Complex Mimics Catalase Activity in HeLa HyPer Cells
preprintsubmitted on 11.11.2020, 22:30 and posted on 12.11.2020, 13:31 by Koudedja Coulibaly, Marion Thauvin, Adyn Melenbacher, Clara testard, Evangelia Trigoni, Amandine Vincent, Martin J. Stillman, Sophie Vriz, Clotilde Policar, Nicolas DELSUC
In this manuscript, we describe the implementation of a combinatorial apporach to synthesize a library of copper complexes, associated with an activity-based screening to discover the first peptidyl di copper complex mimicking CAT redox chemistry. The selected dinuclear complex was studied in detail and characterized for its CAT activity in vitro and in cells. Very interestingly, despite moderate intrinsic catalysis constant, this complex was efficacious in a cellular assay.