These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
2 files

A DNA Aptamer That Inhibits the Formation of Unliganded Receptor Dimer and Ligand-Independent Signaling in Cancer Cells

submitted on 08.09.2020, 09:13 and posted on 09.09.2020, 04:31 by Akihiro Eguchi, Ayaka Ueki, Junya Hoshiyama, Keiko Kuwata, Satoru Nagatoishi, Kouhei Tsumoto, Ryosuke Ueki, Shinsuke Sando

Growth factor receptors are activated through dimerization by the binding of their ligands and play pivotal roles in normal cell function. However, in cancer cells, the overexpression of receptors often causes the formation of unliganded receptor dimers, which can be activated in a ligand-independent manner. Thus, the unliganded receptor dimer is a promising target to inhibit aberrant signaling in cancer. Here, we report an aptamer that inhibits ligand-independent receptor activation via preventing the formation of unliganded receptor dimer. By biasing the receptor monomer–dimer equilibrium to the monomer, this aptamer inhibited aberrant cell signaling caused by the unliganded receptor dimer. This work presents a new possibility of oligonucleotide-based therapeutics for cancer.


Email Address of Submitting Author


The University of Tokyo



ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest


Logo branding