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A Comperehensive Drug Repurposing Study for Covid19 Treatment: Novel Putative DHODH Inhibitors Show Association to Serotonin-Dopamine Receptors

preprint
submitted on 01.08.2020 and posted on 03.08.2020 by Burak Berber, Osman Doluca
Here we discuss the potential of targeting Dihydroorotate dehydrogenase enzyme to help treat Covid 19. Next, we present a very large scale of docking analysis using 7900 drug candidates and 20 Dihydroorotate dehydrogenase structures. Our findings not only identify 28-FDA approved candidate molecules, but also show common characteristics among the candidates, especially their association with serotonin-dopamine receptors. In continuation, we discuss the existing clinical trials for Covid 19 treatment of some of the drug candidates we have identified, supporting that the rest are good candidates.

History

Email Address of Submitting Author

osman.doluca@ieu.edu.tr

Institution

Izmir University of Economics

Country

Türkiye

ORCID For Submitting Author

0000-0003-0412-6148

Declaration of Conflict of Interest

no conflic of interest

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