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A Closed Loop Discovery Robot Driven by a Curiosity Algorithm Discovers Proto-Cells That Show Complex and Emergent Behaviours

preprint
submitted on 11.08.2018 and posted on 13.08.2018 by Jonathan Grizou, Laurie J. Points, Abhishek Sharma, Leroy Cronin

We describe a chemical robotic discovery assistant equipped with a curiosity algorithm (CA) that can efficiently explore a complex chemical system in search of complex emergent phenomena exhibited by proto-cell droplets. The CA-robot is designed to explore proto-cell formulations in an open-ended way with no explicit discovery or optimization target. By applying the CA-robot to the study of multicomponent oil-in-water proto-cell droplets, we discovered an order of magnitude more instances of interesting behaviours than possible with a random parameter search. Among them, a formulation displaying a sudden and highly specific response to temperature was discovered. Six modes of proto-cell droplet motion were identified and classified using a time-temperature phase diagram and probed using a variety of techniques including NMR, which allowed the design of a payload release system triggered by temperature. This work shows how objective free search can lead to the discovery of useful and unexpected properties, with real-world applications in formulation chemistry.

History

Email Address of Submitting Author

lee.cronin@glasgow.ac.uk

Institution

University of Glasgow

Country

UK

ORCID For Submitting Author

0000-0001-8035-5757

Declaration of Conflict of Interest

n/a

Exports