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A Broad-Spectrum, Catalytic Amidation of Sulfonyl Fluorides and Fluorosulfates

preprint
submitted on 17.10.2020, 15:18 and posted on 19.10.2020, 11:00 by Mingjie Wei, Dacheng Liang, Xiaohui Cao, Luo Wenjun, Guojian Ma, Zeyuan Liu, Le Li
A broad-spectrum, catalytic amidation has been developed to prepare various sulfonamides and sulfamates including sterically hindered ones. In addition, the potentials of this methodology in medicinal and process chemistry have been demonstrated by the multidecagram-scale synthesis of an amantadine derivative and the synthesis of the marketed drug Fedratinib for myelofibrosis.

History

Email Address of Submitting Author

lile26@mail.sysu.edu.cn

Institution

Sun Yat-sen University

Country

China

ORCID For Submitting Author

0000-0001-5550-2997

Declaration of Conflict of Interest

Sun Yat-sen University has filed two patent applications.

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